Welcome to the Fianu Lab

Every cell in our body contains nearly identical genetic information (DNA), which is read by transcription and duplicated for inheritance through replication. Both highly regulated processes involve large multi-subunit protein complexes that bind tightly to the DNA template. Deregulation of either process leads to collisions between these complexes, resulting in transcription-replication conflicts (TRCs) that can have harmful consequences. Our research aims to elucidate the molecular mechanisms underlying transcription control and its coordination with DNA replication and repair in health and disease.

We are a team of highly collaborative and enthusiastic researchers, combining our expertise in biochemistry, structural biology—particularly cryo-electron microscopy—and other advanced methodologies to investigate these critical processes.